Channel properties of the splicing isoforms of the olfactory calcium-activated chloride channel Anoctamin 2
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منابع مشابه
Channel properties of the splicing isoforms of the olfactory calcium-activated chloride channel Anoctamin 2
Anoctamin (ANO)2 (or TMEM16B) forms a cell membrane Ca(2+)-activated Cl(-) channel that is present in cilia of olfactory receptor neurons, vomeronasal microvilli, and photoreceptor synaptic terminals. Alternative splicing of Ano2 transcripts generates multiple variants with the olfactory variants skipping exon 14 and having alternative splicing of exon 4. In the present study, 5' rapid amplific...
متن کاملChannel properties of the splicing isoforms of the olfactory calcium - activated chloride channel
The amino acid sequence shown in Fig. 1 D incorrectly included four amino acids encoded by exon 14 of ANO2 that is not found in olfactory cDNA and was not present in the clones used in the paper. GenBank accession numbers KC164759, KC164761, KC164760, and KC164762 have been updated accordingly. This error has no effect on any result or conclusion in the paper. Correction Figure 1. Characterizat...
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The role of calcium-activated chloride channels for renal function is unknown. By immunohistochemistry we demonstrate dominant expression of the recently identified calcium-activated chloride channels, Anoctamin 1 (Ano1, TMEM16A) in human and mouse proximal tubular epithelial (PTE) cells, with some expression in podocytes and other tubular segments. Ano1-null mice had proteinuria and numerous l...
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Calcium (Ca(2+))-activated chloride (Cl(-)) channels (CaCCs) play a role in the modulation of action potentials and synaptic responses in the somatodendritic regions of central neurons. In the vertebrate retina, large Ca(2+)-activated Cl(-) currents (ICl(Ca)) regulate synaptic transmission at photoreceptor terminals; however, the molecular identity of CaCCs that mediate ICl(Ca) remains unclear....
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2014
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.20121093707012014c